T-cell metabolism in autoimmune disease

T-cell metabolism in autoimmune disease

Cancer cells have long been known to fuel their pathogenic growth habits by sustaining a high glycolytic flux, first described almost 90 years ago as the so-called Warburg effect. Immune cells utilize a similar strategy to generate the energy carriers and metabolic intermediates they need to produce biomass and inflammatory mediators. Resting lymphocytes generate energy through oxidative phosph...

T Cell Metabolism in Autoimmune Diseases

Metabolism generates energy for organisms to sustain all kinds of biological functions, such as cell growth and cell apoptosis. The immune system requires an adequate energy supply for its optimal function [1]. During the activation and differentiation of T cells, the balance between glycolysis and lipid oxidation shifts in order to cater for the cell’s energy requirements [2]. There is increas...

Regulatory T Cell Therapy for Autoimmune Disease

It has now been well documented in a variety of models that T regulatory T cells (Treg cells) play a pivotal role in the maintenance of self-tolerance, T cell homeostasis, tumor, allergy, autoimmunity, allograft transplantation and control of microbial infection. Recently, Treg cell are isolated and can be expanded in vitro and in vivo, and their role is the subject of intensive investigation, ...

The third signal in T cell-mediated autoimmune disease?

The initial event in the pathogenesis of autoimmune disease is thought to be the priming of naive autoreactive T cells by an infection with a cross-reactive microorganism. Although such cross-reactive priming should be a common event, autoimmune disease does not frequently develop. This situation is reflected after the immunization of C57BL/6 mice with the neuroantigen myelin oligodendrocyte gl...

Degeneration in Autoimmune Disease Autoreactive T Cells Mediate NK Cell